Mequitazine
Chemical Name:Mequitazine
Molecular Formula:C20H22N2S
Formula Weight:322.47
CAS No.:29216-28-2
Apperance: white powder
Purity:99%
Apperance:white powder
Mequitazine is an H1 antagonist and anticholinergic of the phenothiazine chemical class. It is used to treat allergies and rhinitis.
Seldane
Product name:Terfenadine/Seldane
Chemical Name:seldane
Molecular Formula:C32H41NO2
Formula Weight:471.67
CAS No.:50679-08-8
Purity:98%
Apperance:white powder
Terfenadine is an antihistamine formerly used for the treatment of allergic conditions.
Terfenadine is a prodrug, generally completely metabolized to the active form fexofenadine in the liver by the enzyme cytochrome P450 3A4. Due to its near complete metabolism by the liver immediately after leaving the gut, terfenadine normally is not measurable in the plasma. Terfenadine itself, however, is cardiotoxic at higher doses, while its major active metabolite is not. Terfenadine, in addition to its antihistamine effects, also acts as a potassium channel blocker (Kv11.1 encoded by the gene hERG). Since its active metabolite is not a potassium channel blocker, no cardiotoxicity is associated with fexofenadine.Toxicity is possible after years of continued use with no previous problems as a result of an interaction with other medications such as erythromycin, or foods such as grapefruit. The addition of, or a dosage increase in, these CYP3A4 inhibitors makes it harder for the body to metabolize and remove terfenadine. In larger plasma concentrations, it may lead to toxic effects on the heart’s rhythm (e.g. ventricular tachycardia and torsades de pointes).
Loratadine
CAS:79794-75-5
Molecular formula:C22H23ClN2O2
MW:382.88
Purity:99.29%
Appearance:White crystal powder
Loratadine is a medication used to treat allergies. This includes allergic rhinitis (hay fever) and hives.
Loratadine is indicated for the symptomatic relief of allergy such as hay fever (allergic rhinitis), urticaria (hives), chronic idiopathic urticaria, and other skin allergies. For allergic rhinitis (hay fever), loratadine is effective for both nasal and eye symptoms: sneezing, runny nose, itchy or burning eyes.
Similarly to cetirizine, loratadine attenuates the itching associated with Kimura’s disease
Cetirizine hydrochloride
Product Name:Cetirizine hydrochloride, Cetirizine HCl
Alias: Zyrtec
CAS:83881-52-1
MF:C21H26Cl2N2O3
MW:425.35
EINECS:222-225-5
Assay: 99.45%
Apperance:white Crystalline powder
Cetirizine is a second-generation antihistamine used in the treatment of hay fever, allergies, angioedema, and urticaria.It is a major metabolite of hydroxyzine, and a racemic selective H1 receptor antagonist.
Second-generation antihistamines like cetirizine are less able to cross the blood-brain barrier and therefore have diminished effects on the central nervous system compared to first-generation drugs: for instance they are less likely to induce drowsiness or to interfere with memory formation.
Levocetirizine Dihydrochloride
CAS:130018-87-0
MF:C21H27Cl3N2O3
MW:461.81
Assay:99.8%
Quality Standard: USP/Pharma grade
Appearance:White to off-white crystalline powder
Levocetirizine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.
Levocetirizine is used to treat symptoms of year-round (perennial) allergies in adults and children who are at least 6 months old. It is also used to treat symptoms of seasonal allergies in adults and children who are at least 2 years old.
Levocetirizine is also used to treat itching and swelling caused by chronic urticaria (hives) in adults and children who are at least 6 months old.
Ketotifen fumarate
CAS: 34580-14-8
MF: C23H23NO5S
MW: 425.5
EINECS: 252-100-0
Purity:99.5%
Apperance:white powder
Standard:EP standard
ketotifen fumarate is a first-generation noncompetitive H1-antihistamine and mast cell stabilizer.
Ketotifen relieves and prevents eye itchiness and/or irritation associated with most seasonal allergies. It starts working within minutes after administering the drops. The drug has not been studied in children under three.[The mean elimination half life is 12 hours.Besides its anti-histaminic activity, it is also a functional leukotriene antagonist and a phosphodiesterase inhibitor.
Cyproheptadine hydrochloride
CAS: 41354-29-4
MF: C21H22ClN
MW: 323.86
EINECS: 213-535-1
Purity:99.61%
Apperance:white powder
Standard:USP standard
Cyproheptadine is a first-generation antihistamine with additional anticholinergic, antiserotonergic, and local anesthetic properties.
Medical uses：
1.Cyproheptadine is used to treat allergic reactions (specifically hay fever).It is also used to treat vasomotor mucosal edema, including vasomotor rhinitis and edema of the throat.
2.It has shown effectiveness in the treatment of nightmares, including those related to post-traumatic stress disorder.
3.It has been used in the management of moderate to severe cases of serotonin syndrome, a complex of symptoms associated with the use of serotonergic drugs, such as selective serotonin reuptake inhibitors and monoamine oxidase inhibitors),and in cases of high levels of serotonin in the blood resulting from a serotonin-producing carcinoid tumor.
4.It can also be used as a preventive measure against migraine in children and adolescents.
5.It can relieve SSRI-induced sexual dysfunction and drug-induced hyperhidrosis (excessive sweating).
6.It is also used in the treatment of cyclical vomiting syndrome
7.Use of the drug can stimulate the appetite and may lead to weight gain, which is helpful for underweight people.
8.According to a small study, cyproheptadine hydrochloride has been found to improve sleep, calmness, and mood and energy levels, and to improve both negative and (sometimes even) positive psychotic symptoms in a subgroup of chronic schizophrenics who did not respond (either completely or sufficiently) to other therapies.
9.Cyproheptadine may improve akathisia in patients on antipsychotic medications.
Chlorpheniramine maleate
Molecular Formula:C20H23ClN2O4
Formula Weight:390.86
CAS No.:113-92-8
Appearance:white powder
Purity:99.6%
Standard:BP standard
Chlorpheniramine inhibits the [3H]mepyramine binding to the histamine H1 receptor in guinea pig cortex with IC50 of 8.8 nM. Chlorpheniramine inhibits the proliferation of MCF-7, MDA-MB 231, and Ehrlich cells in a dose-response manner, and significantly reduces the ornithine decarboxylase mRNA translation by 50%-70% at the 250 μM. Chlorpheniramine displaces of [3H]pyrilamine from human histamine receptor subtype 1 expressed in CHO cells with IC50 of 66 nM. Chlorpheniramine displays antimalarial activity against CQS strain (D6) and MDR strain (Dd2) of P. falciparum with IC50 of 61.2 uM and 3.9 uM, respectively. Chlorpheniramine displays cytotoxicity against the proliferation of concanavalin A-induced murine splenic lymphocytes with IC50 of 33.4 μM. Chlorpheniramine treatment in human salivary gland cells more significantly inhibits the histamine-induced [Ca2+]i increase in a concentration-dependent manner with IC50 of 128 nM than that of carbachol-induced [Ca2+]i increase with an IC50 of 43.9 μM.
Uses:
Temporarily relieves these symptoms due to hay fever or other upper respiratory allergies:
runny nose
itchy, watery eyes
sneezing
itching of the nose or throat
Diphenhydramine HCl
CAS: 147-24-0
MF: C17H22ClNO
MW: 291.82
Purity: 99.96%
Apperance:white powder
Standard:BP standard
Diphenhydramine is an antihistamine used to relieve symptoms of allergy, hay fever, and the common cold. These symptoms include rash, itching, watery eyes, itchy eyes/nose/throat, cough, runny nose, and sneezing. It is also used to prevent and treat nausea, vomiting and dizziness caused by motion sickness. Diphenhydramine can also be used to help you relax and fall asleep.
This medication works by blocking a certain natural substance (histamine) that your body makes during an allergic reaction. Its drying effects on such symptoms as watery eyes and runny nose are caused by blocking another natural substance made by your body (acetylcholine).
Diphenhydramine
CAS:58-73-1
MF:C17H21NO
MW:255.35
EINECS:200-396-7
Purity:95.32%
Apperance:white powder
Diphenhydramine is an antihistamine mainly used to treat allergies. It is also used for insomnia, symptoms of the common cold, tremor in parkinsonism, and nausea.It is used by mouth, injection into a vein, and injection into a muscle.Maximal effect is typically around two hours after a dose and effects can last for up to seven hours.
Diphenhydramine is a first-generation antihistamine used to treat a number of conditions including allergic symptoms and itchiness, the common cold, insomnia, motion sickness, and extrapyramidal symptoms.Diphenhydramine also has local anesthetic properties, and has been used as such in people allergic to common local anesthetics such as lidocaine.
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